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World J Surg Oncol. 2014 Jul 16;12:215. doi: 10.1186/1477-7819-12-215.

Sublobar resection versus lobectomy in solid-type, clinical stage IA, non-small cell lung cancer.

Author information

1
Department of Thoracic and Cardiovascular Surgery, Seoul St, Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 137-701, Republic of Korea. jaekpark@catholic.ac.kr.

Abstract

BACKGROUND:

Recent studies have demonstrated that sublobar resection is not inferior to lobectomy for peripheral early lung cancer with ground-glass opacification. However, the effect of sublobar resection on solid-type early lung cancer is controversial. The aim of this study was to compare clinical outcomes of patients who have undergone sublobar resection or lobectomy for solid-type, early-stage, non-small cell lung cancer (NSCLC).

METHODS:

This study was a retrospective review of the records of patients who underwent lobectomy or sublobar resection between March 2000 and September 2010 for clinical stage IA NSCL. Patients with pure ground-glass opacities or death within 30 days after surgery were excluded. Disease-free interval, survival, and prognostic factors were analyzed.

RESULTS:

Thirty-one patients and 133 patients underwent sublobar resection and lobectomy, respectively. There were significant differences in age (P < 0.001), cardiovascular disease (P = 0.001), and diffusing capacity of the lung for carbon monoxide (DLCO) (P < 0.001). The patients with lobectomy had a significantly longer disease-free interval (P < 0.001) and survival (P = 0.001). By multivariate analysis, sublobar resection (P = 0.011), lymphatic vessel invasion (P = 0.006), and number of positive lymph nodes (P = 0.028) were predictors for survival. Sublobar resection (P < 0.001), visceral pleural invasion (P = 0.002), and lymphatic vessel invasion (P < 0.001) were predictors for disease-free interval.

CONCLUSIONS:

Lobectomy should remain the standard surgical procedure for solid-type, clinical stage IA, NSCLC.

PMID:
25027055
PMCID:
PMC4115487
DOI:
10.1186/1477-7819-12-215
[Indexed for MEDLINE]
Free PMC Article

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