Format

Send to

Choose Destination
Antiviral Res. 2014 Sep;109:160-70. doi: 10.1016/j.antiviral.2014.07.005. Epub 2014 Jul 12.

Endothelial cells in dengue hemorrhagic fever.

Author information

1
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA. Electronic address: anon.srikiatkhachorn@umassmed.edu.
2
Faculty of Tropical Medicine, Department of Microbiology and Immunology, Mahidol University, Bangkok, Thailand; Department of Tropical Medicine, Medical Microbiology and Pharmacology, University of Hawaii, USA.

Erratum in

  • Antiviral Res. 2015 Feb;114:47.

Abstract

Therapies to prevent or reverse endothelial dysfunction and vascular leak found in dengue hemorrhagic fever (DHF) have not been identified. In this review we summarize dengue viruses and the spectrum of human disease and highlight evidence of endothelial cell dysfunction in DHF based on studies in patients and mouse and tissue culture models. Evidence suggests that both virus antigen and host immune response, can cause endothelial cell dysfunction and weaken endothelial barrier integrity. We suggest possible therapeutic interventions and highlight how therapies targeting altered endothelial function might be evaluated in animal models and in patients with DHF.

KEYWORDS:

Dengue hemorrhagic fever; Dengue virus; Endothelial barrier integrity; Endothelial cells; Vascular leak

PMID:
25025934
PMCID:
PMC4148486
DOI:
10.1016/j.antiviral.2014.07.005
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center