Format

Send to

Choose Destination
J Pediatr Gastroenterol Nutr. 2014 Nov;59(5):565-70. doi: 10.1097/MPG.0000000000000495.

Efficacy of fecal microbiota transplantation in 2 children with recurrent Clostridium difficile infection and its impact on their growth and gut microbiome.

Author information

1
*Division of Pediatric Gastroenterology, Department of Pediatrics, West Virginia University, Charleston †Division of Gastroenterology, Department of Medicine, Sinai Hospital Program in Internal Medicine ‡Institute for Genome Sciences, University of Maryland School of Medicine §Division of Pediatric Gastroenterology, Department of Pediatrics, Johns Hopkins University ||Division of Gastroenterology, Department of Medicine, Sinai Hospital, Baltimore, Maryland.

Abstract

Fecal microbiota transplantation (FMT) is recognized as an alternative therapeutic modality for recurrent Clostridium difficile infection (RCDI); however, data on its efficacy in children are lacking, including its effect on their growth and fecal microbiota. We report on 2 young children (<3 years old) who failed available therapeutics for RCDI, but responded remarkably well to FMT. Besides resolution of clinical features of C difficile infection (CDI), FMT administration led to marked improvement in their growth, along with increased microbiota diversity, especially proportion of Bacteroides. Our 2 cases illustrate the efficacy of FMT in children with RCDI and its positive effect on their growth and gut microbiota.

PMID:
25023578
DOI:
10.1097/MPG.0000000000000495
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center