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Med Mycol. 2014 Aug;52(6):555-64. doi: 10.1093/mmy/myu029. Epub 2014 Jul 14.

New insights into innate immune control of systemic candidiasis.

Author information

1
Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA lionakism@mail.nih.gov.

Abstract

Systemic infection caused by Candida species is the fourth leading cause of nosocomial bloodstream infection in modern hospitals and carries high morbidity and mortality despite antifungal therapy. A recent surge of immunological studies in the mouse models of systemic candidiasis and the parallel discovery and phenotypic characterization of inherited genetic disorders in antifungal immune factors that are associated with enhanced susceptibility or resistance to the infection have provided new insights into the cellular and molecular basis of protective innate immune responses against Candida. In this review, the new developments in our understanding of how the mammalian immune system responds to systemic Candida challenge are synthesized and important future research directions are highlighted.

KEYWORDS:

innate immunity; monocytes/macrophages; neutrophils; systemic candidiasis

PMID:
25023483
PMCID:
PMC4823972
DOI:
10.1093/mmy/myu029
[Indexed for MEDLINE]
Free PMC Article

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