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Brain Res. 1989 Jul 17;492(1-2):400-3.

Contribution of guanine nucleotide regulatory proteins to prostaglandin hyperalgesia in the rat.

Author information

1
Department of Medicine, University of California, San Francisco 94143.

Abstract

The contribution of the stimulatory guanine nucleotide regulatory protein (Gs) to prostaglandin E2 (PGE2)-induced hyperalgesia was investigated in the hairy skin of the rat hindpaw using the Randall-Selitto paw-withdrawal test. Although without effect alone, guanosine-5'-[gamma-thio]triphosphate (GTP gamma S) and cholera toxin--which activate Gs--both increased, while guanosine-5'-[beta-thio] diphosphate (GDP beta S)--which prevents the activation of Gs--decreased the hyperalgesia induced by PGE2. These data support the hypothesis that the action of PGE2 on primary afferent nociceptors leading to decreases in paw-withdrawal threshold is Gs-mediated.

PMID:
2502301
DOI:
10.1016/0006-8993(89)90929-3
[Indexed for MEDLINE]

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