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Adv Nutr. 2014 Jul 14;5(4):404-17. doi: 10.3945/an.113.005603. Print 2014 Jul.

Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action.

Author information

1
School of Biomedical Sciences, The University of Queensland, Brisbane Australia Department of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh sonaliagun@yahoo.com.
2
School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, Australia.
3
Department of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh.
4
Pharmacy Discipline, Khulna University, Khulna, Bangladesh; and.
5
School of Pharmacy and Biomolecular Sciences, Faculty of Sciences, Liverpool John Moores University, Liverpool, UK.

Abstract

Flavonoids are important natural compounds with diverse biologic activities. Citrus flavonoids constitute an important series of flavonoids. Naringin and its aglycone naringenin belong to this series of flavonoids and were found to display strong anti-inflammatory and antioxidant activities. Several lines of investigation suggest that naringin supplementation is beneficial for the treatment of obesity, diabetes, hypertension, and metabolic syndrome. A number of molecular mechanisms underlying its beneficial activities have been elucidated. However, their effect on obesity and metabolic disorder remains to be fully established. Moreover, the therapeutic uses of these flavonoids are significantly limited by the lack of adequate clinical evidence. This review aims to explore the biologic activities of these compounds, particularly on lipid metabolism in obesity, oxidative stress, and inflammation in context of metabolic syndrome.

PMID:
25022990
PMCID:
PMC4085189
DOI:
10.3945/an.113.005603
[Indexed for MEDLINE]
Free PMC Article

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