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Cell Res. 2014 Oct;24(10):1162-3. doi: 10.1038/cr.2014.93. Epub 2014 Jul 15.

Where cell fate conversions meet Chinese philosophy.

Author information

1
Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China.
2
Institute of Biochemistry and Cell Biology, Shanghai Institutes of Biological Sciences, Shanghai 200031, China.

Abstract

Accumulating evidence indicates that the mesenchymal-epithelial transition (MET) and epithelial-mesenchymal transition (EMT) are basic mechanisms for cell fate conversion and may help us understand both physiologic and pathologic processes such as development and carcinogenesis. Here, we further suggest that mammalian cells fall into two grand divisions, mesenchymal or epithelial; interconversions between these two grand divisions through EMT/MET resonate with some ancient Chinese philosophic ideas.

PMID:
25022900
PMCID:
PMC4185354
DOI:
10.1038/cr.2014.93
[Indexed for MEDLINE]
Free PMC Article

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