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J Dairy Sci. 2014 Sep;97(9):5383-6. doi: 10.3168/jds.2014-8016. Epub 2014 Jul 11.

Short communication: antiviral activity of subcritical water extract of Brassica juncea against influenza virus A/H1N1 in nonfat milk.

Author information

1
Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul 143-701, Republic of Korea.
2
Department of Biotechnology, Konkuk University, Seoul 143-701, Republic of Korea.
3
Department of Agricultural Biotechnology, Seoul National University, Seoul 151-742, Republic of Korea.
4
Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul 143-701, Republic of Korea; Bio/Molecular Informatics Center, Konkuk University, Seoul 143-701, Republic of Korea. Electronic address: hdpaik@konkuk.ac.kr.

Abstract

Subcritical water extract (SWE) of Brassica juncea was studied for antiviral effects against influenza virus A/H1N1 and for the possibility of application as a nonfat milk supplement for use as an "antiviral food." At maximum nontoxic concentrations, SWE had higher antiviral activity against influenza virus A/H1N1 than n-hexane, ethanol, or hot water (80°C) extracts. Addition of 0.5mg/mL of B. juncea SWE to culture medium led to 50.35% cell viability (% antiviral activity) for Madin-Darby canine kidney cells infected with influenza virus A/H1N1. Nonfat milk supplemented with 0.28mg/mL of B. juncea SWE showed 39.62% antiviral activity against influenza virus A/H1N1. Thus, the use of B. juncea SWE as a food supplement might aid in protection from influenza viral infection.

KEYWORDS:

Brassica juncea; antiviral activity; influenza virus; subcritical water extraction

PMID:
25022686
DOI:
10.3168/jds.2014-8016
[Indexed for MEDLINE]
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