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Biomarkers. 2014 Sep;19(6):493-7. doi: 10.3109/1354750X.2014.940502. Epub 2014 Jul 14.

Close relationship between serum hyaluronan levels and vascular function in patients with type 2 diabetes.

Author information

1
Department of Internal Medicine 1 .

Abstract

OBJECTIVE:

To clarify the relationship between serum hyaluronan levels and vascular function in type 2 diabetic patients.

METHODS:

A cross-sectional cohort study.

RESULTS:

In multivariate regression analysis, endothelium-dependent flow-mediated dilation was associated with age and duration of diabetes, but not with serum hyaluronan level, while endothelium-independent nitroglycerine-mediated dilation (NMD) was only associated with serum hyaluronan level (standardized estimate = -0.401, p = 0.003). NMD in the lowest tertile of hyaluronan level was significantly higher than the other tertiles (15.9% versus 12.5% and 10.4%, p = 0.047 and p = 0.002, respectively).

CONCLUSIONS:

Serum hyaluronan level may be useful as a surrogate marker for early changes in the vascular function, which often occurs in patients with diabetes mellitus.

KEYWORDS:

Diabetes; hyaluronan; vascular function

PMID:
25019422
DOI:
10.3109/1354750X.2014.940502
[Indexed for MEDLINE]

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