Format

Send to

Choose Destination
Prostaglandins Other Lipid Mediat. 2014 Oct;113-115:13-20. doi: 10.1016/j.prostaglandins.2014.07.002. Epub 2014 Jul 11.

ω-3 polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer.

Author information

1
Department of Food Science, University of Massachusetts-Amherst, Amherst, MA 01003, United States.
2
Center for Vascular Biology Research and Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, United States.
3
Department of Biomedical Engineering, University of California, Davis, CA 95616, United States.
4
Department of Entomology and Comprehensive Cancer Center, University of California, Davis, CA 95616, United States. Electronic address: bdhammock@ucdavis.edu.
5
Department of Food Science, University of Massachusetts-Amherst, Amherst, MA 01003, United States. Electronic address: guodongzhang@umass.edu.

Abstract

Epidemiological and pre-clinical studies support the anti-tumor effects of ω-3 PUFAs; however, the results from human trials are mixed, making it difficult to provide dietary guidelines or recommendations of ω-3 PUFAs for disease prevention or treatment. Understanding the molecular mechanisms by which ω-3 PUFAs inhibit cancer could lead to better nutritional paradigms and human trials to clarify their health effects. The ω-3 PUFAs exert their biological activities mainly through the formation of bioactive lipid metabolites. Here we discuss the biology of cyclooxygenase, lipoxygenase and cytochrome P450 enzymes-derived ω-3-series lipid metabolites on angiogenesis, inflammation and cancer.

KEYWORDS:

Cyclooxygenase; Cytochrome P450; Lipoxygenase; ω-3 polyunsaturated fatty acids

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center