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Kidney Int Suppl (2011). 2013 Dec;3(5):427-430.

Vitamin D receptor activation: cardiovascular and renal implications.

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Division of Nephrology, Massachusetts General Hospital , Boston, Massachusetts, USA.


The effects of vitamin D receptor activation on cardiovascular diseases, especially hypertension and cardiac dysfunction, are areas of active investigation. This article reviews the current state of knowledge about vitamin D receptor activation with respect to blood pressure, heart, and vascular health, as well as to chronic kidney disease and end-stage renal disease. Potential biological mechanisms, the role of vitamin D-binding protein, and data from observational and randomized controlled trials on this topic are summarized.


chronic kidney disease; end-stage renal disease; hypertension; left ventricular hypertrophy; vitamin D; vitamin D-binding protein

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