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Mol Immunol. 2015 Jan;63(1):80-5. doi: 10.1016/j.molimm.2014.06.018. Epub 2014 Jul 10.

The role of the IL-33/IL-1RL1 axis in mast cell and basophil activation in allergic disorders.

Author information

1
Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany. Electronic address: rohit.saluja@charite.de.
2
University of Groningen, Laboratory of Allergology and Pulmonary Diseases, Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, The Netherlands; GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
3
Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Abstract

Interleukin-33 (IL-33) is a recently discovered cytokine that belongs to the IL-1 superfamily and acts as an important regulator in several allergic disorders. It is considered to function as an alarmin, or danger cytokine, that is released upon structural cell damage. IL-33 activates several immune cells, including Th2 cells, mast cells and basophils, following its interaction with a cell surface heterodimer consisting of an IL-1 receptor-related protein ST2 (IL-1RL1) and IL-1 receptor accessory protein (IL-1RAcP). This activation leads to the production of a variety of Th2-like cytokines that mediate allergic-type immune responses. Thus, IL-33 appears to be a double-edged sword because, in addition to its important contribution to host defence, it exacerbates allergic responses, such as allergic rhinitis and asthma. A major purported mechanism of IL-33 in allergy is the activation of mast cells to produce a variety of pro-inflammatory cytokines and chemokines. In this review, we summarize the current knowledge regarding the genetics and physiology of IL-33 and IL-1RL1 and its association with different allergic diseases by focusing on its effects on mast cells and basophils.

KEYWORDS:

Basophil; IL-1RAcP; IL-1RL1; IL-33; Mast cell; Signal transduction

PMID:
25017307
DOI:
10.1016/j.molimm.2014.06.018
[Indexed for MEDLINE]

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