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Exp Cell Res. 2014 Nov 15;329(1):18-25. doi: 10.1016/j.yexcr.2014.07.003. Epub 2014 Jul 10.

Poly(ADP-ribose) polymerases in double-strand break repair: focus on PARP1, PARP2 and PARP3.

Author information

1
Poly(ADP-ribosyl)ation and Genome Integrity, Equipe labellisée Ligue Nationale Contre Le Cancer, Laboratoire d׳Excellence Medalis, UMR7242, Centre National de la Recherche Scientifique/Université de Strasbourg, Institut de Recherche de l׳Ecole de Biotechnologie de Strasbourg, bld. S. Brant, BP10413,67412 Illkirch, France.
2
Institut de Génétique et de Biologie Moléculaire et Cellulaire; Institut National de la Santé et de la Recherche Médicale, U964; Centre National de la Recherche Scientifique, UMR7104; Université de Strasbourg; Illkirch, 67400, France.
3
Poly(ADP-ribosyl)ation and Genome Integrity, Equipe labellisée Ligue Nationale Contre Le Cancer, Laboratoire d׳Excellence Medalis, UMR7242, Centre National de la Recherche Scientifique/Université de Strasbourg, Institut de Recherche de l׳Ecole de Biotechnologie de Strasbourg, bld. S. Brant, BP10413,67412 Illkirch, France. Electronic address: francoise.dantzer@unistra.fr.

Abstract

Poly(ADP-ribosyl)ation (PARylation) is a post-translational modification of proteins catalysed by Poly(ADP-ribose) polymerases (PARP). A wealth of recent advances in the biochemical and functional characterization of the DNA-dependent PARP family members have highlighted their key contribution in the DNA damage response network, the best characterized being the role of PARP1 and PARP2 in the resolution of single-strand breaks as part of the BER/SSBR process. How PARylation contributes to the repair of double-strand breaks is less well defined but has become recently the subject of significant research in the field. The aim of this review is to provide an overview of the current knowledge concerning the role of the DNA-activated PARP1, PARP2 and PARP3 in cellular response to double-strand breaks (DSB). In addition, we outline the biological significance of these properties in response to programmed DNA lesions formed during physiological processes such as antibody repertoire assembly and diversification.

KEYWORDS:

DNA repair; Homologous recombination; Non homologous end joining; Poly(ADP-ribose) polymerases

PMID:
25017100
DOI:
10.1016/j.yexcr.2014.07.003
[Indexed for MEDLINE]

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