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Bioorg Med Chem Lett. 2014 Aug 15;24(16):3683-9. doi: 10.1016/j.bmcl.2014.06.053. Epub 2014 Jun 26.

Confronting the challenges of discovery of novel antibacterial agents.

Author information

1
SBS Pharma Consulting LLC, Edison, NJ 08820, United States. Electronic address: sheo.singh.215@gmail.com.

Abstract

Bacterial resistance is inevitable and is a growing concern. It can be addressed only by discovery and development of new agents. However the discovery and development of new antibacterial agents are at an all time low. This article broadly examines the historical as well as current status of antibacterial discovery and provides some perspective as how to address some of the challenges.

KEYWORDS:

Antibacterial; Antimicrobial; Discovery strategy; Phenotypic screening; Topoisomerase II

PMID:
25017034
DOI:
10.1016/j.bmcl.2014.06.053
[Indexed for MEDLINE]
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