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Curr Opin Genet Dev. 2014 Jun;26:53-8. doi: 10.1016/j.gde.2014.06.002. Epub 2014 Jul 10.

Chromatin: a capacitor of acetate for integrated regulation of gene expression and cell physiology.

Author information

1
Department of Biological Chemistry, Molecular Biology Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. Electronic address: skurdistani@mednet.ucla.edu.

Abstract

Cancer tissues with lower global levels of histone acetylation display significantly increased rate of tumor recurrence or cancer-related mortality. The function global regulation of histone acetylation serves for the cell or how lower levels of histone acetylation may contribute to a more aggressive cancer phenotype has been unclear. Chromatin and histone modifications are currently thought to regulate only DNA-based processes. However, recent findings have revealed a novel function for global histone acetylation in direct regulation of cellular physiology. I will discuss how chromatin, by regulating the cellular flux of acetate, may integrate control of cellular physiologic state with gene expression and help explain the observations in cancer tissues.

PMID:
25016437
PMCID:
PMC4253552
DOI:
10.1016/j.gde.2014.06.002
[Indexed for MEDLINE]
Free PMC Article

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