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Brain Lang. 2014 Aug;135:96-103. doi: 10.1016/j.bandl.2014.06.003. Epub 2014 Jul 10.

The role of the insula in speech and language processing.

Author information

1
Neurosciences and Mental Health, SickKids Research Institute, Toronto, Canada.
2
Neurosciences and Mental Health, SickKids Research Institute, Toronto, Canada; Diagnostic Imaging, Hospital for Sick Children, Toronto, Canada; Department of Paediatrics, University of Toronto, Toronto, Canada.
3
Neurosciences and Mental Health, SickKids Research Institute, Toronto, Canada; Neurology, Hospital for Sick Children, Toronto, Canada; Department of Paediatrics, University of Toronto, Toronto, Canada. Electronic address: elizabeth.pang@sickkids.ca.

Abstract

Lesion and neuroimaging studies indicate that the insula mediates motor aspects of speech production, specifically, articulatory control. Although it has direct connections to Broca's area, the canonical speech production region, the insula is also broadly connected with other speech and language centres, and may play a role in coordinating higher-order cognitive aspects of speech and language production. The extent of the insula's involvement in speech and language processing was assessed using the Activation Likelihood Estimation (ALE) method. Meta-analyses of 42 fMRI studies with healthy adults were performed, comparing insula activation during performance of language (expressive and receptive) and speech (production and perception) tasks. Both tasks activated bilateral anterior insulae. However, speech perception tasks preferentially activated the left dorsal mid-insula, whereas expressive language tasks activated left ventral mid-insula. Results suggest distinct regions of the mid-insula play different roles in speech and language processing.

KEYWORDS:

Activation Likelihood Estimation (ALE); Articulation; Expressive language; Functional magnetic resonance imaging (fMRI); Insula; Receptive language; Speech production

PMID:
25016092
PMCID:
PMC4885738
DOI:
10.1016/j.bandl.2014.06.003
[Indexed for MEDLINE]
Free PMC Article

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