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Fertil Steril. 2014 Aug;102(2):329-35. doi: 10.1016/j.fertnstert.2014.06.020. Epub 2014 Jul 9.

Clinical significance of melatonin receptors in the human myometrium.

Author information

1
Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida. Electronic address: James.olcese@med.fsu.edu.
2
Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida.

Abstract

OBJECTIVE:

To review and update the research on melatonin receptor expression in the human myometrium, in particular as it pertains to uterine contractility at labor.

DESIGN:

Summary of previous studies with the addition of new data on the transcriptional regulation of melatonin receptor expression in human myometrial cells.

SETTING:

Not applicable.

PATIENT(S):

Late-term pregnant volunteers.

INTERVENTION(S):

Biopsy collection for in vitro analyses provided the original data. More recently, uterine contractions in late-term pregnant volunteers were assessed before, during, and after acute white-light exposure.

MAIN OUTCOME MEASURE(S):

Melatonin receptor signaling in myometrial cells and uterine contractions in late-term pregnant volunteers.

RESULT(S):

Melatonin acts through the MTNR1B melatonin receptor that is expressed in the myometrium at late term to synergistically enhance oxytocin-dependent signaling and contractions. Acute inhibition of endogenous melatonin levels with light reversibly suppresses uterine contractions.

CONCLUSION(S):

These results point to a significant role for circulating melatonin in the timing and degree of uterine contractions in late-term pregnancy. Understanding the regulation of melatonin receptors remains a future objective.

KEYWORDS:

Myometrium; contractions; light; melatonin; receptors

[Indexed for MEDLINE]

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