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Ann Oncol. 2015 Mar;26(3):463-76. doi: 10.1093/annonc/mdu253. Epub 2014 Jul 11.

Treatment of colorectal cancer in older patients: International Society of Geriatric Oncology (SIOG) consensus recommendations 2013.

Author information

1
Department of Medical Oncology, B.O. Cyprus Oncology Centre, Nicosia, Cyprus demetris.papamichael@bococ.org.cy.
2
St Helens Teaching Hospital, St Helens, UK.
3
Department of Radiology, Oncology and Radiation Science, University of Uppsala, Uppsala, Sweden.
4
Hôpital Saint Antoine, Paris, France.
5
Mount Vernon Hospital, Northwood, UK.
6
Abramson Cancer Center at the University of Pennsylvania, Philadelphia, USA.
7
Klinikum Oldenburg, Oldenburg, Germany.
8
Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.
9
Erasmus MC University Medical Centre, Rotterdam Eindhoven Cancer Registry, Comprehensive Cancer Centre South (IKZ), Eindhoven, The Netherlands.
10
Department of Medical Oncology, Institut Curie, Paris Université Versailles Saint-Quentin, Guyancourt, France.
11
Catharina Hospital Eindhoven, Eindhoven Maastricht University Medical Center, Maastricht, The Netherlands.
12
Mayo Clinic, Rochester, USA.
13
Department of Medical Oncology, Hospital Clinico San Carlos, Madrid, Spain.
14
Cancer Medicine and Pathology, University of Leeds, Leeds.
15
Gastrointestinal Unit, Royal Marsden Hospital, London, UK.
16
Digestive Oncology, Leuven Cancer Institute, Leuven, Belgium.
17
SIOG Office, Clinique de Genolier, Genolier, Switzerland.

Abstract

Colorectal cancer (CRC) is one of the most commonly diagnosed cancers in Europe and worldwide, with the peak incidence in patients >70 years of age. However, as the treatment algorithms for the treatment of patients with CRC become ever more complex, it is clear that a significant percentage of older CRC patients (>70 years) are being less than optimally treated. This document provides a summary of an International Society of Geriatric Oncology (SIOG) task force meeting convened in Paris in 2013 to update the existing expert recommendations for the treatment of older (geriatric) CRC patients published in 2009 and includes overviews of the recent data on epidemiology, geriatric assessment as it relates to surgery and oncology, and the ability of older CRC patients to tolerate surgery, adjuvant chemotherapy, treatment of their metastatic disease including palliative chemotherapy with and without the use of the biologics, and finally the use of adjuvant and palliative radiotherapy in the treatment of older rectal cancer patients. An overview of each area was presented by one of the task force experts and comments invited from other task force members.

KEYWORDS:

International Society of Geriatric Oncology; colorectal cancer; geriatric assessment; guidelines; older, SIOG

PMID:
25015334
DOI:
10.1093/annonc/mdu253
[Indexed for MEDLINE]

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