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J Breast Cancer. 2014 Jun;17(2):167-73. doi: 10.4048/jbc.2014.17.2.167. Epub 2014 Jun 27.

Low rates of additional cancer detection by magnetic resonance imaging in newly diagnosed breast cancer patients who undergo preoperative mammography and ultrasonography.

Author information

1
Division of Breast-Endocrine Surgery, Department of Surgery, Asan Medical Center, Seoul, Korea.
2
Department of Surgery, Seoul National University Hospital, Seoul, Korea.
3
Department of Surgery, Mamms Clinic, Seoul, Korea.
4
Department of Surgery, Chung-Ang University College of Medicine, Seoul, Korea.
5
Department of Surgery, Sun General Hospital, Daejeon, Korea.
6
Department of Radiology, Seoul National University Hospital, Seoul, Korea.
7
Department of Pathology, Seoul National University Hospital, Seoul, Korea.

Abstract

PURPOSE:

We evaluated the efficacy of breast magnetic resonance imaging (MRI) for detecting additional malignancies in breast cancer patients newly diagnosed by breast ultrasonography and mammography.

METHODS:

We retrospectively reviewed the records of 1,038 breast cancer patients who underwent preoperative mammography, bilateral breast ultrasonography, and subsequent breast MRI between August 2007 and December 2010 at single institution in Korea. MRI-detected additional lesions were defined as those lesions detected by breast MRI that were previously undetected by mammography and ultrasonography and which would otherwise have not been identified.

RESULTS:

Among the 1,038 cases, 228 additional lesions (22.0%) and 30 additional malignancies (2.9%) were detected by breast MRI. Of these 228 lesions, 109 were suspected to be malignant (Breast Imaging-Reporting and Data System category 4 or 5) on breast MRI and second-look ultrasonography and 30 were pathologically confirmed to be malignant (13.2%). Of these 30 lesions, 21 were ipsilateral to the main lesion and nine were contralateral. Fourteen lesions were in situ carcinomas and 16 were invasive carcinomas. The positive predictive value of breast MRI was 27.5% (30/109). No clinicopathological factors were significantly associated with additional malignant foci.

CONCLUSION:

Breast MRI was useful in detecting additional malignancy in a small number of patients who underwent ultrasonography and mammography.

KEYWORDS:

Breast neoplasms; Limit of detection; Magnetic resonance imaging; Ultrasonography

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