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Europace. 2015 Jan;17(1):117-22. doi: 10.1093/europace/euu176. Epub 2014 Jul 10.

Radiofrequency ablation of accessory pathways in patients with the Wolff-Parkinson-White syndrome: the long-term mortality and risk of atrial fibrillation.

Author information

1
Department of Cardiology, Aarhus University Hospital Skejby, Brendstrupgaardsvej 100, DK-8200 Aarhus N, Denmark rbborregaard@ki.au.dk.
2
Department of Cardiology, Aarhus University Hospital Skejby, Brendstrupgaardsvej 100, DK-8200 Aarhus N, Denmark.
3
Department of Cardiology, Viborg Hospital, Heibergs Alle 4, DK-8800 Viborg, Denmark.
4
Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Alle 43, DK-8200 Aarhus N, Denmark.

Abstract

AIMS:

To assess the long-term mortality and occurrence of post-ablation atrial fibrillation in patients undergoing a radiofrequency ablation for the Wolff-Parkinson-White (WPW) syndrome.

METHODS AND RESULTS:

A retrospective cohort study of patients (N = 362) subjected to radiofrequency ablation of the WPW syndrome at Aarhus University Hospital from 1990 to 2011. A comparison cohort (N = 3619) was generated from the Danish National Board of Health Central Population Registry. We found no significant difference in all-cause mortality when comparing the WPW group with the control group [hazard ratio (HR): 0.77 and confidence interval (CI): 0.47-1.25]. After radiofrequency ablation, the WPW group had a significantly higher risk of atrial fibrillation than the control group (HR: 4.77 and CI: 3.05-7.43). Atrial fibrillation prior to ablation (HR: 4.66 and CI: 2.09-10.41) and age over 50 years (HR: 9.79 and CI: 4.29-22.36) at the time of ablation were independent risk factors for post-ablation atrial fibrillation in the WPW group.

CONCLUSION:

Patients with radiofrequency ablation-treated WPW syndrome have a post-ablation mortality that is similar to the background population. The risk of atrial fibrillation remains high after radiofrequency ablation of the WPW syndrome.

KEYWORDS:

Ablation; Atrial fibrillation; Mortality; WPW; Wolff–Parkinson–White

PMID:
25013013
DOI:
10.1093/europace/euu176
[Indexed for MEDLINE]
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