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Diagn Pathol. 2014 Jul 10;9:141. doi: 10.1186/1746-1596-9-141.

Accumulation of connective tissue growth factor+ cells during the early phase of rat traumatic brain injury.

Author information

1
Institute of Immunology, Third Military Medical University, 30 Gaotanyan Main Street, Chongqing 400038, People's Republic of China. zhangzhiren@yahoo.com.

Abstract

BACKGROUND:

Glial scar formation is a common histopathological feature of traumatic brain injury (TBI). Astrogliosis and expression of transforming growth factor beta (TGF-β) are key components of scar formation and blood-brain barrier modulation. Connective tissue growth factor (CTGF) is considered a cytokine mediating the effects of TGF-β.

METHODS:

Here, we studied the CTGF expression in an open-skull weight-drop-induced TBI, with a focus on the early phase, most amenable to therapy.

RESULTS:

In normal rat brains of our study, CTGF+ cells were rarely observed. Significant parenchymal accumulation of CTGF+ non-neuron cells was observed 72 h post-TBI and increased continuously during the investigating time. We also observed that the accumulated CTGF+ non-neuron cells were mainly distributed in the perilesional areas and showed activated astrocyte phenotypes with typical stellate morphologic characteristics.

CONCLUSION:

Our observations demonstrated the time-dependent and lesion-associated accumulation of cellular CTGF expression in TBI, suggesting a pathological role of CTGF in TBI.

VIRTUAL SLIDES:

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/3963462091241165.

PMID:
25012526
PMCID:
PMC4227000
DOI:
10.1186/1746-1596-9-141
[Indexed for MEDLINE]
Free PMC Article
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