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Biochim Biophys Acta. 2015 May;1849(5):570-81. doi: 10.1016/j.bbagrm.2014.06.021. Epub 2014 Jul 8.

Drosophila Myc: A master regulator of cellular performance.

Author information

1
Department of "Farmacia e Biotecnologie", University of Bologna, Via Selmi 3, 40126 Bologna, Italy. Electronic address: daniela.grifoni@unibo.it.
2
Department of "Bioscienze", University of Milan, Via Celoria 26, 20133 Milan, Italy. Electronic address: paola.bellosta@unimi.it.

Abstract

The identification of the Drosophila homolog of the human MYC oncogene has fostered a series of studies aimed to address its functions in development and cancer biology. Due to its essential roles in many fundamental biological processes it is hard to imagine a molecular mechanism in which MYC function is not required. For this reason, the easily manipulated Drosophila system has greatly helped in the dissection of the genetic and molecular pathways that regulate and are regulated by MYC function. In this review, we focus on studies of MYC in the fruitfly with particular emphasis on metabolism and cell competition, highlighting the contributions of this model system in the last decade to our understanding of MYC's complex biological nature. This article is part of a Special Issue entitled: Myc proteins in cell biology and pathology.

KEYWORDS:

Cancer; Cell competition; Cell growth; MYC; Metabolism

PMID:
25010747
PMCID:
PMC4287454
DOI:
10.1016/j.bbagrm.2014.06.021
[Indexed for MEDLINE]
Free PMC Article

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