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PLoS One. 2014 Jul 10;9(7):e102435. doi: 10.1371/journal.pone.0102435. eCollection 2014.

Spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition.

Author information

1
Biomedical Sciences Research Complex, University of St. Andrews, St. Andrews, United Kingdom.
2
Institute for Molecular Biosciences, University of Graz, Graz, Austria.

Abstract

Spermidine is a natural polyamine involved in many important cellular functions, whose supplementation in food or water increases life span and stress resistance in several model organisms. In this work, we expand spermidine's range of age-related beneficial effects by demonstrating that it is also able to improve locomotor performance in aged flies. Spermidine's mechanism of action on aging has been primarily related to general protein hypoacetylation that subsequently induces autophagy. Here, we suggest that the molecular targets of spermidine also include lipid metabolism: Spermidine-fed flies contain more triglycerides and show altered fatty acid and phospholipid profiles. We further determine that most of these metabolic changes are regulated through autophagy. Collectively, our data suggests an additional and novel lipid-mediated mechanism of action for spermidine-induced autophagy.

PMID:
25010732
PMCID:
PMC4092136
DOI:
10.1371/journal.pone.0102435
[Indexed for MEDLINE]
Free PMC Article

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