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Arch Biochem Biophys. 2014 Nov 1;561:99-108. doi: 10.1016/ Epub 2014 Jul 8.

Osseointegration of metallic devices: current trends based on implant hardware design.

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Department of Biomaterials and Biomimetics and Periodontology and Implant Dentistry, New York University College of Dentistry, New York, USA; Division of Engineering, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates. Electronic address:
Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden.


Osseointegration of metallic devices has been one of the most successful treatments in rehabilitative dentistry and medicine over the past five decades. While highly successful, the quest for designing surgical instrumentation and associated implantable devices that hastens osseointegration has been perpetual and has often been approached as single variable preclinical investigations. The present manuscript presents how the interplay between surgical instrumentation and device macrogeometry not only plays a key role on both early and delayed stages of osseointegration, but may also be key in how efficient smaller length scale designing (at the micrometer and nanometer scale levels) may be in hastening early stages of osseointegration.


Bone; Design; Metallic devices; Osseointegration

[Indexed for MEDLINE]

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