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Clin Gastroenterol Hepatol. 2015 Jan;13(1):183-92. doi: 10.1016/j.cgh.2014.06.028. Epub 2014 Jul 8.

Characteristics of adults in the hepatitis B research network in North America reflect their country of origin and hepatitis B virus genotype.

Author information

1
Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland. Electronic address: marcg@intra.niddk.nih.gov.
2
Hepatology Division, Baylor University Medical Center, Dallas, Texas.
3
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
4
Division of Gastroenterology, Toronto Western and General Hospitals, University Health Network, Toronto, Canada.
5
Division of Gastroenterology, University of California-San Francisco, San Francisco, California.
6
Viral Hepatitis and Liver Clinic, Harborview Medical Center/University of Washington, Seattle, Washington.
7
Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
8
Division of Gastroenterology, Stanford University School of Medicine, Palo Alto, California.
9
University of North Carolina Liver Center, Section of Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
10
Section of Hepatology, Virginia Commonwealth University Health System, Richmond, Virginia.
11
Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri.
12
Pfleger Liver Institute Clinic, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California.
13
Centers for Disease Control and Prevention/Division of Viral Hepatitis/Molecular Epidemiology and Bioinformatics Sequencing Laboratory, Atlanta, Georgia.
14
Penn Center for Viral Hepatitis, University of Pennsylvania Perelman School of Medicine, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.
15
Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan.

Abstract

BACKGROUND & AIMS:

Chronic hepatitis B virus (HBV) infection is an important cause of cirrhosis and hepatocellular carcinoma worldwide; populations that migrate to the United States and Canada might be affected disproportionately. The Hepatitis B Research Network (HBRN) is a cooperative network of investigators from the United States and Canada, created to facilitate clinical, therapeutic, and translational research in adults and children with hepatitis B. We describe the structure of the network and baseline characteristics of adults with hepatitis B enrolled in the network.

METHODS:

The HBRN collected data on the clinical characteristics of 1625 adults with chronic HBV infection who are not receiving antiviral therapy from 21 clinical centers in North America.

RESULTS:

Half of the subjects in the HBRN are men, and the median age is 42 years; 72% are Asian, 15% are black, and 11% are white; with 82% born outside of North America. The most common HBV genotype was B (39%); 74% of subjects were negative for the hepatitis B e antigen. The median serum level of HBV DNA when the study began was 3.6 log10 IU/mL; 68% of male subjects and 67% of female subjects had alanine aminotransferase levels higher than the normal range.

CONCLUSIONS:

The HBRN cohort is used to address important clinical and therapeutic questions for North Americans infected with chronic HBV and to guide health policies on HBV prevention and management in North America.

KEYWORDS:

ALT; Chronic Hepatitis B Virus Infection; HBeAg; USA

PMID:
25010003
PMCID:
PMC4268271
DOI:
10.1016/j.cgh.2014.06.028
[Indexed for MEDLINE]
Free PMC Article

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