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Front Oncol. 2014 Jun 24;4:160. doi: 10.3389/fonc.2014.00160. eCollection 2014.

Ras/Raf/MEK/ERK Pathway Activation in Childhood Acute Lymphoblastic Leukemia and Its Therapeutic Targeting.

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Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University , Newcastle upon Tyne , UK.


Deregulation of the Ras/Raf/MEK/extracellular signal-regulated kinase pathway is a common event in childhood acute lymphoblastic leukemia and is caused by point mutation, gene deletion, and chromosomal translocation of a vast array of gene types, highlighting its importance in leukemia biology. Pathway activation can be therapeutically exploited and may guide new therapies needed for relapsed acute lymphoblastic leukemia and other high risk subgroups.


Ras/Raf/MEK/ERK pathway; acute lymphoblastic leukemia; targeted therapy

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