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Sci Rep. 2014 Jul 10;4:5229. doi: 10.1038/srep05229.

Association of fruit and vegetables with the risk of nasopharyngeal cancer: evidence from a meta-analysis.

Author information

1] Department of Otorhinolaryngology, The Central Hospital of Yiwu City(Affiliated Hospital of Wen Zhou Medical University), Yiwu 322000, China [2].
1] Department of Otolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China, 200092 [2] Ear Institute, Shanghai Jiao Tong University, School of Medicine, Shanghai, China, 200092.


Quantification of the association between the intake of vegetables and fruit and risk of nasopharyngeal cancer (NPC) is controversial. Thus, we conducted a meta-analysis to assess the relationship between vegetables and fruit and NPC risk. Pertinent studies were identified by a search in PubMed, Web of Knowledge and Wan Fang Med Online. Random-effects models were used to calculate summary relative risks (RRs) and the corresponding 95% confidence intervals (CIs). Publication bias was estimated using Egger's regression asymmetry test. Finally, 15 articles comprising 8208 NPC cases were included in this meta-analysis. The combined results showed that there was significant association between vegetables and fruit intake and NPC risk. The pooled RRs were 0.60 (95% CI = 0.47-0.76) for vegetables and 0.63 (95% CI = 0.56-0.70) for fruit. No publication bias was detected. Our analysis indicated that intake of vegetables and fruit may have a protective effect on NPC. Since the potential biases and confounders could not be ruled out completely in this meta-analysis, further studies are needed.

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