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Bioorg Med Chem Lett. 2014 Aug 15;24(16):3952-5. doi: 10.1016/j.bmcl.2014.06.035. Epub 2014 Jun 21.

Lactones from Ficus auriculata and their effects on the proliferation function of primary mouse osteoblasts in vitro.

Author information

1
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China; School of Biochemical Engineering, Hainan Institute of Science and Technology, Haikou 571126, PR China.
2
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China.
3
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China. Electronic address: hchr116@hainnu.edu.cn.
4
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China. Electronic address: chgying123@163.com.
5
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China; College of Chemistry & Environmental Science, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding 071002, PR China.
6
College of Chemistry & Environmental Science, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding 071002, PR China.

Abstract

Bioassay-guided fractionation of the petroleum ether, chloroform and EtOAc extracts of the stems of Ficus auriculata led to the isolation of five new 12-membered lactones (3R,4R)-4-hydroxy-de-O-methyllasiodiplodin (1), 6-oxolasiodiplodin (2) and ficusines A-C (3-5), together with three known related analogues (6-8). The structures of the new compounds were elucidated by comprehensive spectroscopic data. The absolute configurations of 3 and 8 were established by single crystal X-ray diffraction analysis. Compounds 3-5 represent the first 12-membered lactones with a quinone ring unit. Compounds 6 and 7 exhibited significant proliferation function of primary osteoblasts (OBs) in vitro. Especially, the promotion rate of 6 reached 151.55±1.34% (P<0.001) at the concentration of 100 μM.

KEYWORDS:

Chemical constituents; Ficus auriculata; Lactones; Primary osteoblasts

PMID:
25008455
DOI:
10.1016/j.bmcl.2014.06.035
[Indexed for MEDLINE]
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