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J Cutan Med Surg. 2014 Jul-Aug;18(4):229-35.

Measuring the severity of topical 5-fluorouracil toxicity.

Abstract

BACKGROUND:

Topical 5% 5-fluorouracil (5-FU) is known to cause toxicity, such as erythema, pain, and crusting/erosions.

OBJECTIVES:

We sought to develop a scale to measure this toxicity and test the scale for reliability.

METHODS:

A scale was developed involving four parameters: erythema severity, percentage of face involved in erythema, crusting/erosions severity, and percentage of face involved in crusting/erosions. Thirteen raters graded 99 sets of photographs from the Veterans Affairs Keratinocyte Carcinoma Chemoprevention (VAKCC) Trial using these parameters.

RESULTS:

Intraclass correlation overall for 13 raters was 0.82 (95% CI 0.77-0.86). There was no statistically significant trend in reliability by level of training in dermatology.

CONCLUSIONS:

This scale is a reliable method of evaluating the severity of toxicity from topical 5-fluorouracil and can be used by dermatologists and nondermatologists alike.

PMID:
25008439
DOI:
10.2310/7750.2013.13143
[Indexed for MEDLINE]

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