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Cytokine Growth Factor Rev. 2014 Dec;25(6):731-8. doi: 10.1016/j.cytogfr.2014.06.003. Epub 2014 Jun 21.

Innate signaling in the inflammatory immune disorders.

Author information

1
National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China. Electronic address: crystalqiancheng@163.com.
2
National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China.
3
National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China; National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China. Electronic address: caoxt@immunol.org.

Abstract

Pattern recognition receptors (PRRs) of innate immune cells recognize the conserved molecular signatures on pathogens, termed pathogen-associated molecular patterns. PRRs also recognize endogenous damage-associated molecular patterns. Following pathogen infection or tissue damage, the stimulation of PRRs activates distinct but shared signaling pathways that lead to effector mechanisms in innate host defense. PRR signaling is strictly and finely tuned to ensure the appropriate duration and strength to prevent damaging inflammation to the host. Here we attempt to provide a brief background on the agonists and signal transduction pathways of PRRs and summarize the mechanisms underlying the control of PRR signaling, with a particular focus on the recent progress of the involvement of PRR signaling in the inflammatory immune disorders.

KEYWORDS:

Immune regulation; Inflammation; Innate signaling

PMID:
25007741
DOI:
10.1016/j.cytogfr.2014.06.003
[Indexed for MEDLINE]

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