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Can J Psychiatry. 2014 May;59(5):285-8.

Electroencephalographic abnormalities and 5-year outcome in first-episode psychosis.

Author information

1
Director-Prevention and Early Intervention Program for Psychoses (PEPP), London Health Sciences Centre-Victoria Hospital, London, Ontario; Professor of Psychiatry, The University of Western Ontario, London, Ontario.
2
Professor, Departments of Psychiatry, and Epidemiology and Biostatistics, The University of Western Ontario, London, Ontario; Research Psychologist- PEPP, London Health Sciences Centre, London, Ontario.
3
Director-PEPP Montréal, Douglas Institute, Montréal, Quebec; Professor and Canada Research Chair in Early Psychosis, Department of Psychiatry, McGill University, Montreal, Quebec.
4
Associate Professor, Department of Psychiatry, The University of Western Ontario, London, Ontario; Consultant-PEPP, London Health Sciences Centre, London, Ontario.
5
Associate Professor, Department of Psychiatry, The University of Western Ontario, London, Ontario; Consultant-PEPP, Department of Psychiatry, London Health Sciences Centre, London, Ontario.
6
Assistant Professor, Department of Psychiatry, The University of Western Ontario, London, Ontario; Consultant-PEPP, Department of Psychiatry, London Health Sciences Centre, London, Ontario.

Abstract

OBJECTIVE:

To examine the relation of electroencephalographic abnormalities to 5-year outcomes in first-episode psychosis (FEP).

METHODS:

Patients (n = 103) had their baseline electroencephalogram (EEG) classified by modified Mayo Clinic criteria. Symptoms and psychosocial functioning were rated after 5 years of treatment.

RESULTS:

Dysrhythmic EEG was associated with persistence in positive and negative symptoms of psychoses and poorer psychosocial functioning at 5-year follow-up, independently of other characteristics, such as duration of untreated illness or premorbid adjustment. A higher percentage of people with comorbid substance use disorder had normal EEG.

CONCLUSIONS:

Abnormal baseline EEG in FEP is associated with poorer 5-year symptomatic and functional outcome.

PMID:
25007282
PMCID:
PMC4079140
DOI:
10.1177/070674371405900508
[Indexed for MEDLINE]
Free PMC Article

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