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Nat Commun. 2014 Jul 9;5:4378. doi: 10.1038/ncomms5378.

The Opisthorchis viverrini genome provides insights into life in the bile duct.

Author information

1
1] Faculty of Veterinary Science, The University of Melbourne, Melbourne, Victoria 3010, Australia [2].
2
1] Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Republic of Singapore [2].
3
Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Republic of Singapore.
4
Faculty of Veterinary Science, The University of Melbourne, Melbourne, Victoria 3010, Australia.
5
Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA.
6
Liver Fluke and Cholangiocarcinoma Research Center, Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
7
NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 138672, Republic of Singapore.
8
Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore 138672, Republic of Singapore.
9
Research and Diagnostic Center for Emerging Infectious Diseases, Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
10
1] Faculty of Veterinary Science, The University of Melbourne, Melbourne, Victoria 3010, Australia [2] Structural Chemistry Program, Eskitis Institute, Griffith University, Brisbane, Queensland 4111, Australia.
11
Division of Biology, HHMI, California Institute of Technology, Pasadena, California 91125, USA.
12
1] Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Republic of Singapore [2] Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore 138672, Republic of Singapore.
13
1] [2] Department of Biology, University of Copenhagen, Copenhagen 2200, Denmark [3] Princess Al Jawhara Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University, Jeddah 21589, Saudi Arabia [4] Macau University of Science and Technology, Avenida Wai long, Taipa, Macau 999078, China.

Abstract

Opisthorchiasis is a neglected, tropical disease caused by the carcinogenic Asian liver fluke, Opisthorchis viverrini. This hepatobiliary disease is linked to malignant cancer (cholangiocarcinoma, CCA) and affects millions of people in Asia. No vaccine is available, and only one drug (praziquantel) is used against the parasite. Little is known about O. viverrini biology and the diseases that it causes. Here we characterize the draft genome (634.5 Mb) and transcriptomes of O. viverrini, elucidate how this fluke survives in the hostile environment within the bile duct and show that metabolic pathways in the parasite are highly adapted to a lipid-rich diet from bile and/or cholangiocytes. We also provide additional evidence that O. viverrini and other flukes secrete proteins that directly modulate host cell proliferation. Our molecular resources now underpin profound explorations of opisthorchiasis/CCA and the design of new interventions.

PMID:
25007141
PMCID:
PMC4104445
DOI:
10.1038/ncomms5378
[Indexed for MEDLINE]
Free PMC Article
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