Format

Send to

Choose Destination
J Invest Dermatol. 2015 Jan;135(1):229-237. doi: 10.1038/jid.2014.286. Epub 2014 Jul 9.

KIR3DL2/CpG ODN interaction mediates Sézary syndrome malignant T cell apoptosis.

Author information

1
INSERM U976, Saint Louis Hospital, Paris, France.
2
INSERM U976, Saint Louis Hospital, Paris, France; University Paris Diderot, Sorbonne Paris Cité, Paris, France.
3
INSERM U976, Saint Louis Hospital, Paris, France; University Paris Diderot, Sorbonne Paris Cité, Paris, France; Department of Dermatology, AP-HP, Saint Louis Hospital, Paris, France.
4
INSERM U976, Saint Louis Hospital, Paris, France; University Paris Diderot, Sorbonne Paris Cité, Paris, France. Electronic address: anne.marie-cardine@inserm.fr.

Abstract

We previously identified the NK cell receptor KIR3DL2 as a valuable diagnostic and prognostic marker for the detection of the tumoral T cell burden of Sézary syndrome (SS) patients. However, the function of this receptor on the malignant T lymphocyte population remained unexplored. We here demonstrate that engagement of KIR3DL2 by its recently identified ligand CpG oligodeoxynucleotide (ODN) induces the internalization of the receptor and leads to a caspase-dependent apoptosis of malignant T cells. This process of cellular death is correlated to a dephosphorylation of the transcription factor STAT3 (signal transducer and activator of transcription 3), which is found constitutively phosphorylated and activated in Sézary cells. Our results indicate that KIR3DL2 can directly promote SS malignant cell death through the use of CpG ODN.

PMID:
25007046
DOI:
10.1038/jid.2014.286
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center