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J Craniofac Surg. 2014 Jul;25(4):e371-3. doi: 10.1097/SCS.0000000000000860.

The management of an orbital diffuse large B-cell lymphoma.

Author information

1
From the *Division of Otorhinolaryngology, Ospedale Mauriziano Umberto I, Turin, Italy; and †Turin, Italy.

Abstract

BACKGROUND:

The orbit represents a rare site of presentation of non-Hodgkin lymphoma. The diagnosis and management of orbital lymphomas may be challenging because these neoplasms present few specific features.

METHODS:

A 69-year-old woman presented with painless swelling of the left lower eyelid of 5 years' duration. Magnetic resonance imaging and incisional biopsy were necessary to establish a diagnosis of orbital diffuse large B-cell lymphoma. Staging was completed, thanks to a computed tomographic study of the chest and abdomen.

RESULTS:

The patient underwent systemic chemotherapy with 1 regimen (doxorubicin, vincristine, prednisone, 6-mercaptopurine, and methotrexate), followed by 1 R-COMP-14 regimen (rituximab, cyclophosphamide, nonpegylated liposome-encapsulated doxorubicin, vincristine, and prednisone). Complete resolution of the disease was obtained.

CONCLUSIONS:

Although not typically performed by the head and neck surgeon, an understanding of the staging process is crucial for multidisciplinary management of orbital lymphomas.

PMID:
25006952
DOI:
10.1097/SCS.0000000000000860
[Indexed for MEDLINE]
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