Format

Send to

Choose Destination
Clin Psychol Rev. 2014 Jul;34(5):417-27. doi: 10.1016/j.cpr.2014.06.003. Epub 2014 Jun 19.

A review of selected candidate endophenotypes for depression.

Author information

1
Stony Brook University, United States. Electronic address: brandon.goldstein@stonybrook.edu.
2
Stony Brook University, United States.

Abstract

Endophenotypes are proposed to occupy an intermediate position in the pathway between genotype and phenotype in genetically complex disorders such as depression. To be considered an endophenotype, a construct must meet a set of criteria proposed by Gottesman and Gould (2003). In this qualitative review, we summarize evidence for each criterion for several putative endophenotypes for depression: neuroticism, morning cortisol, frontal asymmetry of cortical electrical activity, reward learning, and biases of attention and memory. Our review indicates that while there is strong support for some depression endophenotypes, other putative endophenotypes lack data or have inconsistent findings for core criteria.

KEYWORDS:

Cognitive biases; Cortisol; Depression; Endophenotype; Frontal asymmetry; Neuroticism

PMID:
25006008
PMCID:
PMC4134952
DOI:
10.1016/j.cpr.2014.06.003
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center