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JAMA. 2014 Jul;312(2):182-3. doi: 10.1001/jama.2014.6336.

Antiepileptic drugs for neuropathic pain and fibromyalgia.

Author information

1
Pain Research and Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, England.
2
Department of Anaesthesia, Intensive Care Medicine, Emergency Medicine, and Pain Medicine, Helsinki University Central Hospital, Helsinki, Finland3Institute of Clinical Medicine, University of Helsinki, Finland.

Abstract

CLINICAL QUESTION:

Are antiepileptic drugs associated with reduced pain intensity in patients with neuropathic pain or fibromyalgia?

BOTTOM LINE:

In treating diabetic neuropathy and postherpetic neuralgia compared with placebo, gabapentin and pregabalin are associated with a modest increase in the number of patients experiencing meaningful pain reduction. In treating fibromyalgia, compared with placebo, pregabalin alone is associated with a small increase in the number of patients experiencing meaningful pain reduction. There is insufficient evidence for other antiepileptics.

PMID:
25005656
DOI:
10.1001/jama.2014.6336
[Indexed for MEDLINE]

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