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Zebrafish. 2014 Aug;11(4):379-83. doi: 10.1089/zeb.2014.1002. Epub 2014 Jul 8.

Automatic zebrafish heartbeat detection and analysis for zebrafish embryos.

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1
1 Institute for Applied Computer Science (IAI) , Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany .

Abstract

A fully automatic detection and analysis method of heartbeats in videos of nonfixed and nonanesthetized zebrafish embryos is presented. This method reduces the manual workload and time needed for preparation and imaging of the zebrafish embryos, as well as for evaluating heartbeat parameters such as frequency, beat-to-beat intervals, and arrhythmicity. The method is validated by a comparison of the results from automatic and manual detection of the heart rates of wild-type zebrafish embryos 36-120 h postfertilization and of embryonic hearts with bradycardia and pauses in the cardiac contraction.

PMID:
25003305
PMCID:
PMC4108935
DOI:
10.1089/zeb.2014.1002
[Indexed for MEDLINE]
Free PMC Article
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