Abstract
This study aimed to examine the hepatoprotective effects of the superfine particles of Radix Tetrastigma (SPRT) against CCl4-induced acute liver damage in rats. Animals were treated with SPRT (0.3, 0.6, and 1.2 g/kg) and showed remarkable hepatoprotection against CCl4-induced hepatotoxicity. CCl4 altered various biochemical parameters in rat liver, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA), superoxide dismutase (SOD), histopathological changes, and Bax and caspase-3 expressions. SPRT significantly prevented increases in ALT and AST levels, reduced MDA level, decreased Bax and caspase-3 protein expression, enhanced SOD activity, and provided significant amelioration in the histopathological lesions. These findings suggested that SPRT has significant protective effect against acute hepatotoxicity induced by CCl4 in rats.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Animals
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Antioxidants / metabolism
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Biomarkers / blood
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Carbon Tetrachloride
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Caspase 3 / metabolism
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Chemical and Drug Induced Liver Injury / blood
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Chemical and Drug Induced Liver Injury / drug therapy*
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Chemical and Drug Induced Liver Injury / enzymology
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Chemical and Drug Induced Liver Injury / pathology
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Herbal Medicine
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Liver / enzymology
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Liver / pathology
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Male
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Malondialdehyde / metabolism
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Particle Size*
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Phytotherapy
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Plant Extracts / chemistry*
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use*
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Protective Agents / chemistry*
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Protective Agents / pharmacology
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Protective Agents / therapeutic use*
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Rats
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Superoxide Dismutase / metabolism
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bcl-2-Associated X Protein / metabolism
Substances
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Antioxidants
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Biomarkers
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Plant Extracts
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Protective Agents
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bcl-2-Associated X Protein
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Malondialdehyde
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Carbon Tetrachloride
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Superoxide Dismutase
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Caspase 3