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Nat Rev Neurol. 2014 Aug;10(8):447-58. doi: 10.1038/nrneurol.2014.108. Epub 2014 Jul 8.

The investigation of acute optic neuritis: a review and proposed protocol.

Author information

1
Departments of Neurology and Ophthalmology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, Netherlands.
2
Department of Radiology, Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, Netherlands.
3
University of Calgary, Canada.
4
The National Institute of Neurology and Neurosurgery, Mexico City, Mexico.
5
University of Sydney, Australia.
6
Tohoku University Graduate School of Medicine, Japan.
7
Mayo Clinic, Rochester, USA.
8
Hôpital Neurologique Pierre Wertheimer, Bron Cedex, France.
9
NeuroCure Clinical Research Center, Charité-Universitätsmedizin Berlin, Germany.
10
University Hospital Zürich, Switzerland.
11
Cliniques Universitaires Saint-Luc, Brussels, Belgium.
12
August Pi i Sunyer Biomedical Research Institute (IDIBAPS)-Hospital Clinic, Barcelona, Spain.
13
Moorfields Eye Hospital and The National Hospital for Neurology and Neurosurgery, London, UK.

Erratum in

  • Nat Rev Neurol. 2014 Aug;10(8):i.

Abstract

Optic neuritis is an inflammatory optic neuropathy that affects many patients with multiple sclerosis (MS) at some point during their disease course. Differentiation of acute episodes of MS-associated optic neuritis from other autoimmune and inflammatory optic neuropathies is vital for treatment choice and further patient management, but is not always straightforward. Over the past decade, a number of new imaging, laboratory and electrophysiological techniques have entered the clinical arena. To date, however, no consensus guidelines have been devised to specify how and when these techniques can be most rationally applied for the diagnostic work-up of patients with acute optic neuritis. In this article, we review the literature and attempt to formulate a consensus for the investigation of patients with acute optic neuritis, both in standard care and in research with relevance to clinical treatment trials.

PMID:
25002105
DOI:
10.1038/nrneurol.2014.108
[Indexed for MEDLINE]

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