Synthesis and characterization of some acyl thiourea derivatives of chitosan and their biocidal activities

Int J Biol Macromol. 2014 Sep:70:199-207. doi: 10.1016/j.ijbiomac.2014.05.068. Epub 2014 Jun 2.

Abstract

Three acyl derivatives of chitosan (CS) with different side chains were synthesized and their structures were characterized. Their swelling behavior was investigated. The antifungal behavior of these chitosan derivatives was investigated in vitro on the mycelial growth, sporulation and germination of conidia or sclerotia of the sugar-beet pathogens, Rhizoctonia solani K"uhn (AG2-2) and Sclerotium rolfsii Sacc. All the prepared derivatives had a significant inhibiting effect on the different stages of development on the germination of conidia or sclerotia of all the investigated fungi. In the absence of chitosan and its derivative, R. solani exhibited the fastest growth of the fungi studied.

Keywords: Antifungal activity 1; Characterization; Chitosan thiourea; Swelling behavior.

MeSH terms

  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology
  • Chitosan / chemical synthesis
  • Chitosan / chemistry*
  • Disinfectants / chemistry*
  • Disinfectants / pharmacology*
  • Microbial Sensitivity Tests
  • Spectroscopy, Fourier Transform Infrared
  • Thermogravimetry
  • Thiourea / chemistry*
  • X-Ray Diffraction

Substances

  • Antifungal Agents
  • Disinfectants
  • Chitosan
  • Thiourea