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Nat Rev Clin Oncol. 2014 Sep;11(9):509-24. doi: 10.1038/nrclinonc.2014.111. Epub 2014 Jul 8.

Therapeutic vaccines for cancer: an overview of clinical trials.

Author information

1
Centro de Investigación Medica Aplicada (CIMA) and Clínica Universitaria (CUN), Universidad de Navarra, Spain.
2
Department of Immunology, The Norwegian Radium Hospital, Cancer Research Institute, University of Oslo, Norway.
3
Department of Medical Oncology, VUmc Cancer Center Amsterdam, 1081 HV Amsterdam, Netherlands.
4
Department of Haematology/Oncology, Johannes Gutenberg University, Germany.
5
San Raffaele Foundation Scientific Institute, Italy.
6
Department of Medical Oncology, Institut Curie, France.
7
CRC Department of Medical Oncology, Christie Hospital NHS Trust, UK.
8
South West Wales Cancer Institute, Singleton Hospital, UK.
9
Clinical Division of Oncology, Department of Medicine I, Comprehensive Cancer Centre Vienna, Medical University Vienna, Austria.
10
International Medical Press, UK.
11
Cancer Centre Karolinska, Department of Oncology, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.

Abstract

The therapeutic potential of host-specific and tumour-specific immune responses is well recognized and, after many years, active immunotherapies directed at inducing or augmenting these responses are entering clinical practice. Antitumour immunization is a complex, multi-component task, and the optimal combinations of antigens, adjuvants, delivery vehicles and routes of administration are not yet identified. Active immunotherapy must also address the immunosuppressive and tolerogenic mechanisms deployed by tumours. This Review provides an overview of new results from clinical studies of therapeutic cancer vaccines directed against tumour-associated antigens and discusses their implications for the use of active immunotherapy.

PMID:
25001465
DOI:
10.1038/nrclinonc.2014.111
[Indexed for MEDLINE]

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