Format

Send to

Choose Destination
Virology. 2014 Aug;462-463:377-87. doi: 10.1016/j.virol.2014.04.018. Epub 2014 Jul 4.

The elusive function of the hepatitis C virus p7 protein.

Author information

1
Division of BioMedical Sciences, Faculty of Medicine, Memorial University, Newfoundland, St. John׳s, Canada.
2
Division of BioMedical Sciences, Faculty of Medicine, Memorial University, Newfoundland, St. John׳s, Canada. Electronic address: rodney.russell@med.mun.ca.

Abstract

Hepatitis C virus (HCV) is a major global health burden with 2-3% of the world's population being chronically infected. Persistent infection can lead to cirrhosis and hepatocellular carcinoma. Recently available treatment options show enhanced efficacy of virus clearance, but are associated with resistance and significant side effects. This warrants further research into the basic understanding of viral proteins and their pathophysiology. The p7 protein of HCV is an integral membrane protein that forms an ion-channel. The role of p7 in the HCV life cycle is presently uncertain, but most of the research performed to date highlights its role in the virus assembly process. The aim of this review is to provide an overview of the literature investigating p7, its structural and functional details, and to summarize the developments to date regarding potential anti-p7 compounds. A better understanding of this protein may lead to development of a new and effective therapy.

KEYWORDS:

Assembly; HCV; Hepatitis C virus; Viroporin; p7

PMID:
25001174
DOI:
10.1016/j.virol.2014.04.018
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center