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Protein Cell. 2014 Oct;5(10):750-60. doi: 10.1007/s13238-014-0083-7. Epub 2014 Jul 8.

Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control.

Author information

1
Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, 80045, USA, caiguo.zhang@ucdenver.edu.

Abstract

Eukaryotic cells contain numerous iron-requiring proteins such as iron-sulfur (Fe-S) cluster proteins, hemoproteins and ribonucleotide reductases (RNRs). These proteins utilize iron as a cofactor and perform key roles in DNA replication, DNA repair, metabolic catalysis, iron regulation and cell cycle progression. Disruption of iron homeostasis always impairs the functions of these iron-requiring proteins and is genetically associated with diseases characterized by DNA repair defects in mammals. Organisms have evolved multi-layered mechanisms to regulate iron balance to ensure genome stability and cell development. This review briefly provides current perspectives on iron homeostasis in yeast and mammals, and mainly summarizes the most recent understandings on iron-requiring protein functions involved in DNA stability maintenance and cell cycle control.

PMID:
25000876
PMCID:
PMC4180463
DOI:
10.1007/s13238-014-0083-7
[Indexed for MEDLINE]
Free PMC Article

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