Format

Send to

Choose Destination
Arch Gerontol Geriatr. 1989 Mar;8(2):123-7.

Age- and diabetes-accelerated glycation in the human aorta.

Author information

1
Second Department of Internal Medicine, Kobe University School of Medicine, Japan.

Abstract

The extent of glycation in pieces of human aorta was estimated by determining the content of furosine, which is derived from fructose-lysine through acid hydrolysis. Glycation of human aorta was found to increase with advancing age. A significant positive correlation was found between the degree of atherosclerosis and the furosine level in the aorta in subjects over 60 years of age. Furthermore, the furosine level in the aortae of diabetic patients was significantly higher than that in normal subjects of the same age. These results suggest not only that glycation in the aorta may increase with aging and with the development of arteriosclerosis, but also that diabetes may be related as well to premature aging as to arteriosclerosis.

PMID:
2500075
DOI:
10.1016/0167-4943(89)90056-3
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center