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Curr Opin Microbiol. 2014 Jun;19:70-5. doi: 10.1016/j.mib.2014.05.021. Epub 2014 Jul 5.

Metagenomic small molecule discovery methods.

Author information

  • 1Laboratory of Genetically Encoded Small Molecules, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, United States.
  • 2Laboratory of Genetically Encoded Small Molecules, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, United States. Electronic address: sbrady@rockefeller.edu.

Abstract

Metagenomic approaches to natural product discovery provide the means to harvest bioactive small molecules synthesized by environmental bacteria without the requirement of first culturing these organisms. Advances in sequencing technologies and general metagenomic methods are beginning to provide the tools necessary to unlock the unexplored biosynthetic potential encoded by the genomes of uncultured environmental bacteria. Here, we highlight recent advances in sequence-based and functional-based metagenomic approaches that promise to facilitate antibiotic discovery from diverse environmental microbiomes.

PMID:
25000402
PMCID:
PMC4135586
DOI:
10.1016/j.mib.2014.05.021
[PubMed - indexed for MEDLINE]
Free PMC Article
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