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Clin Nucl Med. 2014 Sep;39(9):849-51. doi: 10.1097/RLU.0000000000000409.

123I-ioflupane SPECT findings of pantothenate kinase-associated neurodegeneration.

Author information

1
From the *Department of Radiology, University of Washington, and †Neuroimaging and Biotechnology Laboratory, Department of Radiology, University of Washington, Seattle, WA.

Abstract

We present a case of a 72-year-old man with a 9-year history of memory decline and 7-year history of parkinsonian symptoms. An MRI demonstrated an "eye-of-the-tiger" sign in the basal ganglia, suggestive of pantothenate kinase-associated neurodegeneration (formerly known as Hallervorden-Spatz syndrome). An 123I-ioflupane SPECT scan demonstrated absence of radiotracer uptake in the caudate nuclei and putamina. Genetic testing confirmed a single-point mutation in the PANK2 gene, consistent with pantothenate kinase-associated neurodegeneration.

PMID:
24999676
DOI:
10.1097/RLU.0000000000000409
[Indexed for MEDLINE]

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