Format

Send to

Choose Destination
FEBS Lett. 2014 Aug 25;588(17):3170-9. doi: 10.1016/j.febslet.2014.06.058. Epub 2014 Jul 3.

Tumour-suppressive microRNA-24-1 inhibits cancer cell proliferation through targeting FOXM1 in bladder cancer.

Author information

1
Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
2
Department of Functional Genomics, Chiba University Graduate School of Medicine, Chiba, Japan.
3
Department of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
4
Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan. Electronic address: enokida@m.kufm.kagoshima-u.ac.jp.

Abstract

Here, we found that microRNA-24-1 (miR-24-1) is significantly reduced in bladder cancer (BC) tissues, suggesting that it functions as a tumour suppressor. Restoration of mature miR-24-1 inhibits cancer cell proliferation and induces apoptosis. Forkhead box protein M1 (FOXM1) is a direct target gene of miR-24-1, as shown by genome-wide gene expression analysis and luciferase reporter assay. Overexpressed FOXM1 is confirmed in BC clinical specimens, and silencing of FOXM1 induces apoptosis in cancer cell lines. Our data demonstrate that the miR-24-1-FOXM1 axis contributes to cancer cell proliferation in BC, and elucidation of downstream signalling will provide new insights into the molecular mechanisms of BC oncogenesis.

KEYWORDS:

Bladder cancer; Forkhead box protein M1; Tumour suppressor; microRNA; microRNA-24-1

PMID:
24999187
DOI:
10.1016/j.febslet.2014.06.058
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center