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J Crohns Colitis. 2014 Nov;8(11):1506-15. doi: 10.1016/j.crohns.2014.06.004. Epub 2014 Jul 4.

Incidence and initial disease course of inflammatory bowel diseases in 2011 in Europe and Australia: results of the 2011 ECCO-EpiCom inception cohort.

Author information

1
Digestive Disease Centre, Medical Section, Herlev University Hospital, Copenhagen, Denmark; 1st Department of Medicine, Semmelweis University, Budapest, Hungary. Electronic address: veghzsuzsi@gmail.com.
2
Digestive Disease Centre, Medical Section, Herlev University Hospital, Copenhagen, Denmark.
3
Nicosia Private Practice, Cyprus.
4
IBD Centre ISCARE, Charles University, Prague, Czech Republic.
5
Department of Medicine, Amager Hospital, Amager, Denmark.
6
Medical Department, The National Hospital of the Faroe Islands, Torshavn, Faroe Islands.
7
1st Division of Internal Medicine and Division of Gastroenterology, Faculty of Medicine, University of Ioannina, Ioannina, Greece.
8
1st Department of Medicine, Semmelweis University, Budapest, Hungary.
9
Department of Gastroenterology and Hepatology, Soroka Medical Centre and Ben-Gurion University of the Negev, Beer Sheva, Israel.
10
U.O.Gastroenterologia ed Endoscopia, Ospedale Maggiore di Crema, Crema, Italy; On behalf of the EpiCom Northern Italy centre based in Crema, Cremona, Firenze, Forlì & Padova and Reggio Emilia, Italy.
11
On behalf of the EpiCom Northern Italy centre based in Crema, Cremona, Firenze, Forlì & Padova and Reggio Emilia, Italy; U.O. Gastroenterologia ed Endoscopia Digestiva, University of Ioannina, Forlì, Italy.
12
Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
13
Department of Gastroenterology, State University of Medicine and Pharmacy, Chisinau, Republic of Moldova.
14
Department of Paediatric Gastroenterology, Centre of Mother and Child, Chisinau, Republic of Moldova.
15
Hospital de Vale de Sousa, Porto, Portugal.
16
Department of Gastroenterology, Hospital de São João, Porto, Portugal; Department of Pharmacology and Therapeutics, Oporto Medical School, Porto, Portugal; MedInUP-Centre for Drug Discovery and Innovative Medicines, University of Porto, Porto, Portugal.
17
Clinic of Gastroenterology, University of Medicine 'Victor Babes', Timisoara, Romania.
18
Gastroenterology Department, POVISA Hospital, Vigo, Spain.
19
Gastroenterology Department, Complexo Hospitalario Universitario de Vigo, Vigo, Spain.
20
Department of Gastroenterology, St Vincent's Hospital, Melbourne, Victoria, Australia.
21
Department of Medical Gastroenterology, Gentofte Hospital, Copenhagen, Denmark.

Abstract

BACKGROUND AND AIMS:

The aim of the present study was to validate the IBD (inflammatory bowel diseases) incidence reported in the 2010 ECCO-EpiCom (European Crohn's and Colitis Organization-Epidemiological Committee) inception cohort by including a second independent inception cohort from participating centers in 2011 and an Australian center to investigate whether there is a difference in the incidence of IBD between Eastern and Western European countries and Australia.

METHODS:

Fourteen centers from 5 Eastern and 9 Western European countries and one center from Australia participated in the ECCO-EpiCom 2011 inception cohort. Patients' data regarding disease type, socio-demographic factors, extraintestinal manifestations and therapy were entered into the Web-based EpiCom database, www.ecco-epicom.eu.

RESULTS:

A total of 711 adult patients were diagnosed during the inclusion year 2011, 178 (25%) from Eastern, 461 (65%) from Western Europe and 72 (10%) from Australia; 259 (37%) patients were diagnosed with Crohn's disease, 380 (53%) with ulcerative colitis and 72 (10%) with IBD unclassified. The mean annual incidence rate for IBD was 11.3/100,000 in Eastern Europe, 14.0/100,000 in Western Europe and 30.3/100,000 in Australia. Significantly more patients were diagnosed with complicated disease at diagnosis in Eastern Europe compared to Western Europe (43% vs. 27%, p=0.02).

CONCLUSION:

Incidence rates, disease phenotype and initial treatment characteristics in the 2011 ECCO-EpiCom cohort were not significantly different from that reported in the 2010 cohort.

KEYWORDS:

Inception cohort; Incidence; Inflammatory bowel diseases

PMID:
24998983
DOI:
10.1016/j.crohns.2014.06.004
[Indexed for MEDLINE]

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