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Curr Opin Genet Dev. 2014 Aug;27:92-101. doi: 10.1016/j.gde.2014.05.002. Epub 2014 Jul 5.

A mechanistic link between gene regulation and genome architecture in mammalian development.

Author information

1
David Geffen School of Medicine, Department of Biological Chemistry, Jonsson Comprehensive Cancer Center, and the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, CA 90095, USA.
2
David Geffen School of Medicine, Department of Biological Chemistry, Jonsson Comprehensive Cancer Center, and the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, CA 90095, USA. Electronic address: kplath@mednet.ucla.edu.
3
David Geffen School of Medicine, Department of Biological Chemistry, Jonsson Comprehensive Cancer Center, and the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, CA 90095, USA. Electronic address: matthew.denholtz@gmail.com.

Abstract

The organization of chromatin within the nucleus and the regulation of transcription are tightly linked. Recently, mechanisms underlying this relationship have been uncovered. By defining the organizational hierarchy of the genome, determining changes in chromatin organization associated with changes in cell identity, and describing chromatin organization within the context of linear genomic features (such as chromatin modifications and transcription factor binding) and architectural proteins (including Cohesin, CTCF, and Mediator), a new paradigm in genome biology was established wherein genomes are organized around gene regulatory factors that govern cell identity. As such, chromatin organization plays a central role in establishing and maintaining cell state during development, with gene regulation and genome organization being mutually dependent effectors of cell identity.

PMID:
24998386
PMCID:
PMC4125518
DOI:
10.1016/j.gde.2014.05.002
[Indexed for MEDLINE]
Free PMC Article

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