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Curr Opin Cell Biol. 2014 Oct;30:68-73. doi: 10.1016/j.ceb.2014.06.003. Epub 2014 Jul 5.

Stressing the limits of focal adhesion mechanosensitivity.

Author information

1
James Franck Institute, Institute for Biophysical Dynamics and Physics Department, University of Chicago, Chicago, IL, United States.
2
James Franck Institute, Institute for Biophysical Dynamics and Physics Department, University of Chicago, Chicago, IL, United States. Electronic address: gardel@uchicago.edu.

Abstract

Focal adhesion assembly and maturation often occurs concomitantly with changes in force generated within the cytoskeleton or extracellular matrix. To coordinate focal adhesion dynamics with force, it has been suggested that focal adhesion dynamics are mechanosensitive. This review discusses current understanding of the regulation of focal adhesion assembly and force transmission, and the limits to which we can consider focal adhesion plaques as mechanosensitive entities.

PMID:
24998185
PMCID:
PMC4459577
DOI:
10.1016/j.ceb.2014.06.003
[Indexed for MEDLINE]
Free PMC Article
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